Meghan, who is a champion of gender equality, is likely to raise the issue when her tour of South Africa with husband Harry and their son Archie starts on Monday.
The Duke and Duchess of Sussex flew to their friend's wedding on a commercial jet after criticism of their use of private jets. "Women and children are under siege", Mr Ramaphosa said, describing South Africa as one of "the most unsafe places in world to be a woman".
"It would be unusual for them not to address it in the current climate given how much of their official programme, particularly the Duchess's, is about women and women's issues", a source told the Daily Mail, as cited by Fox News. The couple was blessed with a baby boy - Archie, earlier this year.
According to a royal source, Meghan and Harry "hope to" give fans a glimpse of their son during the tour, but baby Archie has not been included in the official schedule.
Recently, the bride, who created her own wedding dress, opened up about her friendship with Meghan, saying that nothing has changed since she met Prince Harry and joined the royal family. The Duke will travel alone to Botswana, Malawi and Angola. The wedding also saw other attendees from the royal family, including Princesses Eugenie and Beatrice, who are both longtime friends of Nonoo.
Despite royals usually not involving themselves in the politics of their host country, it is understood the couple will not be able to ignore the urgent issue during their nine-day tour there.
This can not be confirmed because of strict security measures that doesn't allow the media to be present when Prince Harry and Meghan land and set foot on African soil.
The duo will also speak to Grace Machel, the widow of late President Nelson Mandela before the royal tour wraps up on October 2.