The party also said that anti-semitism complaints "account for about 0.1% of the Labour Party membership", and that "polls show anti-semitism is more prevalent among Conservative than Labour supporters".
In an outspoken attack on the Labour leader, Ephraim Mirvis said a "new poison - sanctioned from the top" had "taken root" in the party.
Labour issued a statement saying Corbyn is a "lifelong campaigner against antisemitism and has made absolutely clear it has no place in our party and society".
The chief rabbi, who is the spiritual leader of the United Synagogue, said Labour's claim it had investigated all cases of anti-Semitism in its ranks was a "mendacious fiction".
However, nine of his lawmakers quit the party in February, citing the leadership's handling of the accusations among their reasons, and in May Britain's equality watchdog launched an investigation into possible discrimination by Labour. Our trudge and faith manifesto units out our policies to assemble this'.
Alfred Dubs, who escaped from the Nazis in Czechoslovakia as a child in 1939, said the rabbi had gone a bit far.
While Mirvis didn't explicitly tell British citizens not to vote for Labour, he said: "I simply pose the question: What will the result of this election say about the moral compass of our country?"
"The party leadership have never understood that their failure is not just one of procedure, which can be remedied with additional staff or new processes".
The most senior clergyman in the Church of England, Archbishop of Canterbury Justin Welby said the country must take Mirvis's words seriously.
In an editorial for The Cases, Ephraim Mirvis criticised Jeremy Corbyn for being "complicit in prejudice" and "unfit for region of job".
"British Jews are acutely anxious about the proliferation of anti-Semitism in the official party of opposition".
In December of a year ago, the Simon Wiesenthal Center, a Jewish human rights organisation that researches the Holocaust and contemporary anti-Semitism, added Corbyn's lack of response on anti-Semitism to their annual list of top ten worst incidents.
In an article for the Times, he asked people to "vote with their conscience" in the election.
"It's unprecedented for a major political party - a potential party of government - to be perpetuating anti-Semitism".
Labour's faith envoy Stephen Timms told Talk Radio "there has been a problem of antisemitism in the Labour Party, there's no doubt about that and steps have been taken to deal with it".
Liberal Democrat leader Jo Swinson said it was "hugely worrying" that the Chief Rabbi felt compelled to make such an intervention in an election.
Johnson said it was a "serious business" when the chief rabbi criticized the opposition leader.
"It speaks volumes about the genuine fear that people in the Jewish community feel about Jeremy Corbyn and his inability to tackle anti-Semitism in the Labour Party", she said.