Meanwhile, Arsenal's interim manager Freddie Ljungberg said Arsenal can still finish in the Premier League top four despite a 2-2 draw at Norwich City on Sunday that extended the club's winless streak in the league to six games. The former Holland global, 35, still plays professional football with Qatari club Al-Shahania SC.
The champions drew 2-2 at Newcastle United on Saturday afternoon, with the Reds' subsequent win over Brighton sending them 11 points clear.
Presenter Gabby Logan joked: 'It's rudimentary, but a friend in need is a friend indeed.
"We never give up". We have another alternative in other players and I'm thinking about that.
Aguero got the victor on their previous visit to Turf Moor towards the back end of last season with a scrappy finish that barely crossed the line but put City within two wins of their second consecutive Premier League title.
Why it's the Premier League meeting between Sean Dyche's mid-table troopers and the reigning champions of England.
City will make one enforced change with midfielder Ilkay Gundogan suspended after accumulating five bookings this season.
Since losing Vincent Kompany at the end of last season and Aymeric Laporte with a serious knee injury in August, the City boss has largely deployed the Brazilian at centre-back, even when defenders John Stones and Nicolas Otamendi have been fit and available.
"And he plays and he leaves Stones on the bench". And as soon as we lose that desire to win and think it's done then it definitely is done.
"They can't think too much about the teams in front".
Jurgen Klopp's men have only dropped two points so far this term to establish their dominant position, but Guardiola rejected the suggestion that belief is fading among his own squad ahead of a Tuesday trip to Burnley that precedes the Manchester derby.
"He relies on Fernandinho just because of his character and because of his skills".
Burnley possible starting XI: Pope; Bardsley, Tarkowski, Mee, Taylor; Hendrick, Westwood, Cork, McNeil; Wood, Barnes.
"I think it's typical for this league, through the whole history, that there are many, many teams involved [in the title race]", said Guardiola.