"Foreign nationals, other than immediate family of U.S. citizens and permanent residents, who have travelled in China within the last 14 days will be denied entry into the United States for this time", Health Secretary Alex Azar said.
Sars was also estimated to have cost the global economy more than $US30bn.
The mandatory order, from the Centers for Disease Control and Prevention (CDC), was the first of its kind in around 60 years.
This is the first federal quarantine issued in more than 50 years, the CDC said.
Vietnam halted all air travel to China, Italy banned incoming flights, the first European Union country to do so, and Qatar Airways became the first Middle East carrier to suspend flights to China.
Yesterday, an unidentified passenger tried to leave the base and was ordered to stay until health officials had cleared him or her.
The man has since self-isolated at his home, leaving home twice to seek medical care.
The northern city of Tianjin, with a population of about 15 million, suspended all schools and businesses until further notice, joining other cities across China in implementing measures aimed at curbing the spread of the pathogen.
China is waging a fight of unprecedented proportions against the epidemic, as the country had reported 11,791 confirmed cases of novel coronavirus and 259 deaths from the disease in 31 provincial-level regions and the Xinjiang Production and Construction Corps by the end of Friday.
The new virus does not appear to be as deadly as SARS, but there have been more cases overall. However, the husband recently did not travel to China, the CDC said.
Chinese officials in central Hubei province, where the outbreak began, said Saturday at least 259 people have died and almost 12,000 have been infected by the virus.
The action will effectively prevent any foreign national who has been to China within the last two weeks from entering the country, with exceptions made for immediately family of American citizens and permanent residents.
Starting on Sunday, the USA will funnel all flights coming from China to just a few airports including John F. Kennedy Airport in New York and Chicago's O'Hare International Airport, according to The New York Times. These are Atlanta, Honolulu, Los Angeles, San Francisco, Seattle, the John F. Kennedy International Airport in NY and the O'Hare International Airport in Chicago, acting deputy secretary of Homeland Security Ken Cuccinelli announced.
The travel industry has expressed concern about a growing financial hit from coronavirus fears.
"Just as the World Health Organization recommended against travel restrictions, the US rushed to go in the opposite way".
Federal health officials on Saturday confirmed an eighth case of the coronavirus in the U.S., concerning a person who traveled from China.
Apple on Saturday became the latest company to announce the closure of its stores in mainland China to prevent the spread of the virus, with the measure set to remain on place until February 9.
The novel strain of coronavirus, which can cause pneumonia, shares symptoms with a number of other illnesses, including fever and cough, so the only way to know definitively if a person has the virus is to test a sample.
Despite criticisms that the Chinese government has received given the outbreak which oftentimes seems to be getting out of control, Dr. Tedros said that China should be commended. "There are 4 million Chinese-Americans in this country".
A second Xiamen flight landed soon afterwards carrying Hubei residents from Kota Kinabalu, a popular coastal tourist destination in Malaysia. The government said they would be quarantined in a nearby city, Manesar.